The Best Things Come in Small Packages– Vesicular Delivery of Weak Base Antipsychotics

Good things come in small packages

Current ovarian cancer treatments based on surgery/chemotherapy show limited efficacy. Targeting immunosuppression is a requirement for the effectiveness of novel promising anti-tumor immunotherapies. Our latest work in preclinical models shows that nanoparticle-mediated delivery of immunostimulatory microRNAs specifically to tumor-associated leukocytes is sufficient to re-program immunological...

Formulation of mefenamic acid loaded transfersomal gel by thin film hydration technique and hand shaking method

Objective(s): The aim of present study is to formulate mefenamic acid transdermal gel based on vesicular drug delivery approaches.Materials and Methods: For the preparation of mefenamic acid transdermal gel, transfersomes were selected as colloidal carriers. Transfersomes were prepared by hand shaking and thin film hydration techniques. The obtained transfersomes were characterized for vesicula...

Phase-Conversion Nanoparticle Contrast Agents: Do Good Things Come in Small Packages?

راهبرد‌های افزایش نفوذ در دارورسانی پوستی

Transdermal drug delivery (TDD) is a non-invasive, topical administration method for therapeutic agents. Transdermal delivery also has advantages including providing release for long periods of time, improving patient compliance, and generally being inexpensive. Despite these advantages, the use of TDD has been limited by innate barrier functions of the skin. Only small (<500 Da), lipophilic mo...

The effect of education on base the Theory of Planned Behavior toward normal delivery in pregnant women with intention elective cesarean

Introduction: Finding an appropriate training method for encouraging pregnant women toward performing vaginal delivery is necessary because of increasing growth of cesarean and its associated complications. Methods: This semi- experimental study was carried out on a sample of 200 pregnant women who referred to the obstetrics offices of Zahedan during winter 2010 to summer 2011 by using non- pro...